AMPIVIEW^® HPV High Risk RNA Probes series

超過 99% 的子宮頸癌病例以及相當一部分口咽癌和肛門生殖器癌的原因是持續感染高風險型人類乳突病毒（HPV）。目前已鑑定出200多種HPV類型。 HPV 可分為高危險型（16、18、31、33、34、35、39、45、51、52、56、58、59、66、68 和 70 型）和低危險型（6、11、42、43 和 44 型）。

Enzo Life Sciences 提供 AMPIVIEW^® HPV High Risk RNA Probes採用 LoopRNA™ ISH 技術，利用 Digxigenin 標記探針，提供高靈敏度、不會破壞樣本，直接在光學顯微鏡下觀察，可視化組織和細胞中的 HPV 基因型的空間生物學。

產品特色

可測得低至 1-3 Low copies

Detection of HPV 16/18 in SiHa cells (1-3 HPV integrated copies) with A. AMPIVIEW^® HPV 16/18 sense RNA probes to detect viral DNA only and B. AMPIVIEW^® HPV 16/18 antisense RNA probes to detect both viral DNA and viral RNA in cells.

相較其他市售品牌，AMPIVIEW® RNA probe 可產生高訊號和低背景雜訊。

HPV high-risk detection in cervical cancer tissue with A. AMPIVIEW^® HPV High-Risk RNA probes (red) combined with POLYVIEW^® PLUS AP and HIGHDEF^® Red AP Chromogen and B. Competitor’s high-risk HPV probes and detection reagents tested according to manufacturer’s instructions. Note the distinct staining pattern between cancer and benign cells with AMPIVIEW^® compared to the non-specific staining in the stroma compared to the cancer signal with the leading competitor’s probes.

擁有與 PCR 結果相似的靈敏度，同時保持樣本的形態

產品應用範例

AMPIVIEW^® HPV High-Risk RNA probes (ENZGEN148), is a cocktail of HPV types 16, 18, 31, 33 and 51 specific probes that detect high-risk HPV types that are associated with either condyloma or cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS).

AMPIVIEW^® HPV 6/11 RNA probes (ENZ-GEN145), is a cocktail of HPV types 6 and type 11 specific probes that detect HPV types that are associated with low risk CIN, recurrent respiratory papillomatosis, conjunctival papillomas/ carcinomas and condylomata acuminata (genital warts) among others.

AMPIVIEW^® HPV 16/18 RNA probes (ENZ-GEN146), is a cocktail of HPV type 16 and type 18 specific probes that detect high risk CIN and CIS.

AMPIVIEW^® HPV 31/33/51 RNA probes (ENZ-GEN147), is a cocktail of HPV type 31, type 33 and type 51 specific probes that detect HPV types that are associated with both low- and high-risk CIN and CIS. HPV type 33 is implicated in other cutaneous lesions while type 51 was found in genital warts too.

產品資訊

Cat. No.	Product Name
ENZ-GEN145	AMPIVIEW^® HPV 6/11 RNA Probes Set
ENZ-GEN146	AMPIVIEW^® HPV 16/18 RNA Probes Set
ENZ-GEN147	AMPIVIEW^® HPV 31/33/51 RNA Probes Set
ENZ-GEN148	AMPIVIEW^® HPV High-Risk RNA Probes Set
ENZ-GEN320	AMPIVIEW^® HPV HR-15 (AS) DNP RNA Probes Set